Anastrozole is the generic form of Arimidex
Anastrozole is indicated in treating breast cancer in postmenopausal women It is often given to women whose cancer has progresed ever after taking Tamoxifen (aka Nolvadex or Soltamox)
Anastrozole is also used in an anabolic steroid cycles that contain aromatizing steroids, the user protects against gynecomastia and water retention. This will also assist in protecting against high blood pressure.
Do not use anastrozole if you are pregnant. It could harm the unborn baby.
Anastrozole may not work as well if you take it together with estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings).
Anastrozole may increase your risk of a stroke or blood clot. Call your doctor at once if you have sudden numbness or weakness, (especially on one side of the body), sudden severe headache, slurred speech, or problems with vision or balance.
Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.
Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).
Anastrozole may also be used for purposes not listed in this medication guide.
You should not use this medication if you are allergic to anastrozole, if you are breast-feeding a baby, or if you have not yet completed menopause. Anastrozole is not for use in men or children.
To make sure anastrozole is safe for you, tell your doctor if you have:
Anastrozole can decrease bone mineral density, which may increase your risk of developing osteoporosis. Your bone mineral density may need to be tested before and during treatment with anastrozole.
FDA pregnancy category D. Do not use anastrozole if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
It is not known whether anastrozole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using anastrozole.
You may need to take a pregnancy test before using anastrozole, to make sure you are not pregnant.
Anastrozole is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take anastrozole with or without food.
You may need to keep taking this medication for up to 5 years. Follow your doctor's instructions.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
This medicine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Anastrozole may not work as well if you take it together with an estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings). Before you start taking anastrozole, tell your doctor if you also take tamoxifen or estrogen.
Other drugs may interact with anastrozole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Your pharmacist can provide more information about anastrozole.
Dosage forms: 1
Special Note: [uses, dosing may vary] Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
*Ovulation Induction: [1-5 mg PO qd x5 days] Start: day 3 of menstrual cycle
Renal Dosing: [no adjustment]
Hepatic Dosing: mild-mod impairment/cirrhosis: no adjustment; severe impairment: not defined
Peds dosing is currently unavailable or not applicable for this drug.
anastrozole, aromatase inhibitor
Lactation: Safety Unknown
Monitoring Parameters: pregnancy test at baseline; consider BMD, lipid panel
Look/Sound-Alike Drug Names: anastrozole confused with: anagrelide; letrozole
Metabolism: liver primarily; CYP450: none
Excretion: urine 60% (10% unchanged), feces; Half-life: 50h
Subclass: Hormonal Oncologics 4: Antiestrogens; Infertility
Mechanism of Action
inhibits enzymatic androgen conversion to estrogen, reducing hormone receptor positive cancer cell growth (aromatase inhibitor)
Manufacturer: KNOLL PHARMA & PISA LABS, Generic Formula/Presentation
Approximate Retail Price: 1 mg (30 ea): $128.00