Retrovir-Generic, zidovudine 50mg/5ml x 100ml syrup Zidovir

Zidovudine Dosing Information

Usual Adult Dose for HIV Infection:

Oral: 300 mg orally every 12 hours or 200 mg orally every 8 hours
IV: 1 mg/kg by IV infusion over 1 hour, every 4 hours around the clock, for a total daily dose of 5 to 6 mg/kg; maximum of 200 mg/dose

Duration: Therapy should be continued for as long as the patient tolerates, or until the patient is switched to another antiretroviral agent.

Usual Adult Dose for Nonoccupational Exposure:

300 mg orally every 12 hours or 200 mg orally every 8 hours, in combination with efavirenz plus (lamivudine or emtricitabine) or lopinavir-ritonavir plus (lamivudine or emtricitabine)
Prophylaxis should be initiated as soon as possible, preferably within 72 hours of exposure.

Duration: 28 days

Usual Adult Dose for Occupational Exposure:

300 mg orally every 12 hours or 200 mg orally every 8 hours
Prophylaxis should begin promptly, preferably within 1 to 2 hours postexposure.

Duration: Generally 28 days; however, the exact duration of therapy may differ based on the institution's protocol

Usual Adult Dose for Reduction of Perinatal Transmission of HIV:

Maternal dosing: 100 mg orally 5 times a day until start of labor; however, most authorities would also consider the standard oral dosages of 300 mg every 12 hours or 200 mg every 8 hours
During labor and delivery: 2 mg/kg by IV infusion over 1 hour followed by a continuous IV infusion of 1 mg/kg/hr until clamping of the umbilical cord

Therapy should begin at 14 to 34 weeks gestation. Neonates should also be treated for 6 weeks. Despite the use of this regimen, transmission to infants may still occur in some cases.

Usual Pediatric Dose for HIV Infection:

IV infusion:
6 weeks to 12 years:
Intermittent: 120 mg/m2 IV every 6 hours
Continuous: 20 mg/m2 IV per hour

13 years or older: 1 mg/kg by IV infusion over 1 hour, every 4 hours around the clock, for a total daily dose of 5 to 6 mg/kg; maximum of 200 mg/dose

Oral:
6 weeks to less than 18 years:
Based on body weight:
4 to less than 9 kg: 12 mg/kg orally twice a day or 8 mg/kg orally 3 times a day
9 to less than 30 kg: 9 mg/kg orally twice a day or 6 mg/kg orally 3 times a day
30 kg or more: 300 mg orally twice a day or 200 mg orally 3 times a day

Based on body surface area: 240 mg/m2 orally twice a day or 160 mg/m2 orally 3 times a day

The dosage calculated by body weight may not be the same as the dosage calculated by body surface area in some cases.

Usual Pediatric Dose for Reduction of Perinatal Transmission of HIV:

Premature infants:
Oral: 2 mg/kg orally every 12 hours
IV: 1.5 mg/kg IV every 12 hours

Increase dosage frequency to every 8 hours at 4 weeks of age in neonates less than 30 weeks gestation at birth and at 2 weeks of age in neonates 30 to less than 35 weeks gestation at birth.

Full-term infants, 0 to 6 weeks:
Oral: 2 mg/kg orally every 6 hours
IV: 1.5 mg/kg IV every 6 hours

Oral treatment with zidovudine syrup should start at 8 to 12 hours after birth and should continue through 6 weeks of age. IV zidovudine may be administered to neonates unable to receive oral dosing and should be infused over 30 minutes.

What other drugs will affect zidovudine?

Before taking zidovudine, tell your doctor if you are also using:

• atovaquone (Mepron);

• doxorubicin (Adriamycin);

• fluconazole (Diflucan);

• ganciclovir (Cytovene);

• interferon-alfa (Roferon, Intron, Rebetron);

• methadone (Dolophine, Methadose);

• nelfinavir (Viracept);

• phenytoin (Dilantin);

• probenecid (Benemid);

• ribavirin (Rebetol, Ribasphere, Copegus Virazole);

• ritonavir (Norvir); or

• stavudine (Zerit).

This list is not complete and there may be other drugs that can interact with zidovudine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

All Wholesale Prices are marked as F.O.B.-Panama / F.O.B.-Mexico; We ship via Commercial Air Cargo, DHL, Fedex, UPS or other private carriers. All our generic medicines are produced in W.H.O-Geneva or FDA Inspected and Approved Laboratories. This is a Generic drug and not a brand name medicine; because of it's generic form a compulsary licence(s) were issued in numerous countries allowing their fabrication, importation and distribution where they are legally permitted; and not in violation of any accords in regards to trademarks and patents. Be sure you are able to import these generic pharmaceuticals into your country prior to ordering; as some countries will not allow their importation.