AFUMIX 37.5MG/500MG 4 TAB {fluconazole/tinidazole}

AFUMIX 37.5MG/500MG 4 TAB {fluconazole/tinidazole}
Price: $50.00
Product ID : fluconazole_tinidazole
Manufacturer: ALTIA

Description

AFUMIX 37.5/500MG {FLUCONAZOLE / TINIDAZOLE}

BRAND: AFUMIX
Generic: fluconazole 37.5mg + tinidazole 500mg

INDICATIONS & USAGE: Indicated for treating vaginal yeast and fungal infections caused by Candida, Tricomona & Gardnerela bacteria.

INDICADO POR:  AFUMIX está indicado en las infecciones vaginales mixtas causadas por Candida, Trichomona, Gardnerella vaginalis y bacterias anaerobias.

Why is AFUMIX  prescribed?

AFUMIX is used to treat fungal infections called candidiasis (also known as thrush or yeast infections). These include vaginal infections, throat infections, and fungal infections elsewhere in the body, such as infections of the urinary tract, peritonitis (inflammation of the lining of the abdomen), and pneumonia. AFUMIX is also prescribed to guard against candidiasis in some people receiving bone marrow transplants, and is used to treat meningitis (brain or spinal cord inflammation) caused by another type of fungus.

In addition, AFUMIX is now being prescribed for fungal infections in kidney and liver transplant patients, and fungal infections in patients with AIDS.

Most important fact about AFUMIX

Strong allergic reactions to AFUMIX, although rare, have been reported. Symptoms may include hives, itching, swelling, sudden drop in blood pressure, difficulty breathing or swallowing, diarrhea, or abdominal pain. If you experience any of these symptoms, notify your doctor immediately.

How should you take AFUMIX?

You can take AFUMIX with or without meals.

Take AFUMIX exactly as prescribed, and continue taking it for as long as your doctor instructs. You may begin to feel better after the first few days; but it takes weeks or even months of treatment to completely cure certain fungal infections.

  • If you miss a dose...
    Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take double doses.
  • Storage instructions...
    AFUMIX tablets should be stored at normal room temperature. Avoid exposing them to temperatures above 86°F.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking AFUMIX.

The most common side effect for people taking more than one dose is nausea.

For women taking a single dose to treat vaginal infection, the most common side effects are abdominal pain, diarrhea, headache, and nausea; changes in taste, dizziness, and indigestion may occur less often.

  • Other side effects may include:
    Abdominal pain, diarrhea, headache, irregular heartbeat, skin rash, vomiting

Why should AFUMIX not be prescribed?

Do not take AFUMIX if you are sensitive to any of its ingredients or have ever had an allergic reaction to similar drugs, such as ketoconazole. Make sure your doctor is aware of any drug reactions you have experienced.

Avoid combining AFUMIX with the heartburn medication cisapride. The combination has been known to trigger heartbeat irregularities and other cardiac problems.

Special warnings about AFUMIX

Your doctor will watch your liver function carefully while you are taking AFUMIX.

If your immunity is low and you develop a rash, your doctor should monitor your condition closely. You may have to stop taking AFUMIX if the rash gets worse.

In a small group of patients, drugs similar to AFUMIX have caused irregular heartbeats. If you develop such symptoms while taking AFUMIX, contact your doctor.

Possible food and drug interactions when taking AFUMIX

If AFUMIX is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining AFUMIX with the following:


Blood-thinning drugs such as warfarin
Antidiabetic drugs such as glipizide, glyburide, and tolbutamide
Astemizole
Cisapride
Cyclosporine
Hydrochlorothiazide
Phenytoin
Rifabutin
Rifampin
Tacrolimus
Terfenadine
Theophylline
Ulcer medications such as Tagamet

Special information if you are pregnant or breastfeeding

The effects of AFUMIX during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. AFUMIX appears in breast milk and could affect a nursing infant. If AFUMIX is essential to your health, your doctor may advise you to stop breastfeeding until your treatment with AFUMIX is finished.

Recommended dosage for AFUMIX

ADULTS

For vaginal infections

The usual treatment is a single 150-milligram dose.

For throat infections

The usual dose for candidiasis of the mouth and throat is 200 milligrams on the first day, followed by 100 milligrams once a day. You should see results in a few days, but treatment should continue for at least 2 weeks to avoid a relapse. For candidiasis of the esophagus (gullet) the usual dose is 200 milligrams on the first day, followed by 100 milligrams once a day. A dose of 400 milligrams a day can also be taken if your infection is more severe. Treatment should continue for a minimum of 3 weeks and for at least 2 weeks after symptoms have stopped.

For systemic (bodywide) infections

Doses of up to 400 milligrams per day are sometimes prescribed.

For urinary infections and peritonitis

Doses range from 50 to 200 milligrams per day.

For cryptococcal meningitis

The usual dose is 400 milligrams on the first day, followed by 200 milligrams once a day. Treatment should continue for 10 to 12 weeks once tests of spinal fluid come back negative. For AIDS patients, a 200-milligram dose taken once a day is recommended to prevent relapse.

Prevention of candidiasis during bone marrow transplantation

The usual dose is 400 milligrams once a day.

If you have kidney disease, your doctor may have to reduce your dosage.

CHILDREN

For throat infections

The usual dose for candidiasis of the mouth and throat is 6 milligrams for each 2.2 pounds of the child's weight on the first day, and 3 milligrams per 2.2 pounds once a day after that.

The duration of treatment is the same as that for adults.

For yeast infections of the esophagus

Cadidiasis in the upper digestive canal is usually treated with a dose of 6 milligrams per 2.2 pounds of body weight on the first day, and half that amount once daily thereafter. Daily doses of up to 12 milligrams per 2.2 pounds of body weight are sometimes prescribed.

For systemic (bodywide) infections

The drug has been given at 6 to 12 milligrams per 2.2 pounds of weight per day.

For cryptococcal meningitis

The usual dose is 12 milligrams per 2.2 pounds of body weight per day on the first day, and 6 milligrams per 2.2 pounds per day after that. Treatment will last 10 to 12 weeks after the fungus disappears.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

  • Symptoms of AFUMIX overdose may include:
    Hallucinations, paranoia

All Wholesale Prices are marked as F.O.B.-Panama / F.O.B.-Mexico; We ship via Commercial Air Cargo, DHL, Fedex, UPS or other private carriers. This medicine was produced by a W.H.O-Geneva or FDA Inspected Approved Laboratories. This is a MEXICAN PRODUCED drug and not an American brand name medicine; because of it's form compulsary licence(s) were issued in numerous countries allowing their fabrication, importation and distribution where they are legally permitted; and not in violation of any accords in regards to trademarks and patents. Be sure you are able to import this pharmaceutical into your country prior to ordering; as some countries will not allow their importation.


SPANISH / ESPANOL:

AFUMIX {fluconazol y tinidazol}

Tabletas Antimicótico de amplio espectro (Fluconazol, tinidazol)

FORMA FARMACÉUTICA Y FORMULACIÓN:

Cada TABLETA contiene: Fluconazol 37.5 mg y Tinidazol 500 mg Excipiente, c.b.p. 1 tableta.

INDICACIONES TERAPÉUTICAS:

AFUMIX está indicado en las infecciones vaginales mixtas causadas por Candida, Trichomona, Gardnerella vaginalis y bacterias anaerobias.

FARMACOCINÉTICA Y FARMACODINAMIA:

Fluconazol pertenece a un nuevo grupo de antimicóticos, los triazoles, que inhiben la síntesis de los esteroles en los hongos. Administrado por vía oral se absorbe bien sin que la absorción se vea alterada por los alimentos; su biodisponibilidad es mayor al 90%.

Las concentraciones plasmáticas máximas en ayunas se logran entre 30 y 90 minutos, con una vida media plasmática de eliminación de 30 horas, siendo las concentraciones proporcionales a la dosis. El 90% de los niveles séricos estables se alcanzan alrededor del 4o. ó 5o. día de su administración diaria. Su unión a proteínas es de 11 a 12%.

Fluconazol penetra adecuadamente a todos los líquidos del organismo, logrando concentraciones en saliva y esputo similares a las plasmáticas; en líquido cefalorraquídeo logra el 80% de las concentraciones alcanzadas en plasma.

Fluconazol logra concentraciones superiores a las séricas en estrato córneo, piel y glándulas sudoríparas. La principal vía de eliminación es renal, recuperándose aproximadamente 80% de la dosis administrada como droga sin cambio, siendo la depuración de fluconazol proporcional a la depuración de creatinina.

La prolongada vida media de eliminación plasmática da la base para el tratamiento de la candidiasis vaginal.

Por otro lado, tinidazol actúa destruyendo o inhibiendo la síntesis del ADN de las bacterias anaerobias y protozoarios; se absorbe rápido y completamente por vía oral, alcanzando concentraciones plasmáticas máximas a las dos horas con una vida media de eliminación de 12 a 14 horas.

Tinidazol se elimina por vía renal principalmente y en menor grado por las heces en una proporción de 5 a 1; su unión a las proteínas es de 12%.

CONTRAINDICACIONES: Pacientes con discrasias sanguíneas, trastornos neurológicos de tipo orgánico, hipersensibilidad conocida al medicamento u otros compuestos del grupo de los azoles, terfenadina.

PRECAUCIONES GENERALES:

En aquellos pacientes en quienes se presente un aumento significativo de las enzimas hepáticas, deberá valorarse el riesgo contra el beneficio de continuar el tratamiento con fluconazol, ya que en estudios histopatológicos se ha encontrado necrosis hepática sin que ésta sea atribuible al mismo, ya que estos pacientes habían recibido otros medicamentos potencialmente hepatotóxicos; tinidazol se ha asociado a diversos trastornos neurológicos como mareo, vértigo, ataxia, neuropatía periférica y en raras ocasiones con convulsiones, por lo que si se presentan signos de anormalidades neurológicas debe suspenderse el tratamiento.

RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA:

Uso durante el embarazo: Deberá evitarse el uso durante el embarazo y la lactancia.

REACCIONES SECUNDARIAS Y ADVERSAS: AFUMIX es bien tolerado; sin embargo, puede presentarse náuseas, vómito, anorexia, dolor abdominal, diarrea, flatulencia y sabor metálico.

También se ha reportado rash cutáneo, prurito, urticaria y edema angioneurótico, por lo que se debe discontinuar el tratamiento si se desarrollan lesiones bulosas o eritema multiforme.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO GÉNERO:

Fluconazol aumenta el tiempo de protrombina después de la administración de warfarina en hombres sanos, por lo que se recomienda vigilancia en pacientes que estén recibiendo anticoagulantes del tipo de la cumarina. Se ha demostrado que el uso de fluconazol prolonga la vida media de las sulfonilureas, por lo que se debe tener en mente que la coadministración puede ocasionar hipoglucemias.

La coadministración con múltiples dosis de hidroclorotiazida incrementa las concentraciones plasmáticas de fluconazol en 40%, sin que se requiera cambio en el esquema de dosificación de fluconazol.

La administración conjunta de fluconazol y fenitoína puede aumentar los niveles de esta última. La administración conjunta de fluconazol y rifampicina redujo la vida media de fluconazol. La administración conjunta de fluconazol y teofilina afecta la depuración de ésta última.

La administración conjunta de fluconazol con terfenadina a dosis de 400 mg o más produce aumento de los niveles plásmaticos de terfenadina.

El uso concomitante con cisaprida puede desencadenar alteraciones cardiacas, con rifabutin, tacrolimus y zidovudina.

Se ha señalado también aumento de los niveles séricos de éstas.

Debe evitarse el consumo de bebidas alcohólicas por la posibilidad de desarrollar reacción tipo disulfiram.

ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO:

En pacientes con SIDA o cáncer se han observado cambios en las pruebas funcionales renales y hematológicas, así como anormalidades hepáticas. El tinidazol puede causar leucopenia transitoria.

PRECAUCIONES EN RELACIÓN CON EFECTOS DE CARCINOGÉNESIS, MUTAGÉNESIS, TERATOGÉNESIS Y SOBRE LA FERTILIDAD: Hasta el momento no se han demostrado efectos carcinogénicos, mutagénicos, teratogénicos ni sobre la fertilidad.

DOSIS Y VÍA DE ADMINISTRACIÓN: Oral.

La dosis recomendada es de 2 tabletas cada 12 horas durante un día o 4 tabletas juntas como dosis única.

MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACIÓN O INGESTA ACCIDENTAL: En caso de que exista, se recomienda tratamiento sintomático con medidas de soporte y lavado gástrico; si es necesario, una diuresis forzada aumentará la velocidad de eliminación. Una sesión de hemodiálisis con duración de 3 horas disminuye los niveles plasmáticos en aproximadamente 50%.

PRESENTACIÓN: Caja con 4 tabletas.

RECOMENDACIONES SOBRE ALMACENAMIENTO: Consérvese a temperatura ambiente a no más de 30°C y en lugar seco.

LEYENDAS DE PROTECCIÓN: Su venta requiere receta médica.

LABORATORIOS SENOSIAIN S. A. de C. V. Camino a San Luis Rey No. 221, Ex-Hacienda Santa Rita, 38137 Celaya, Gto. México

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Reg. Núm. 489M2002, SSA IV: JEAR-103761/R2002

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