Etoposide

Pronunciation: (e-TOE-poe-side)
Class: Podophyllotoxin derivative

Trade Names:
Etopophos
- Injection, lyophilized powder for solution 100 mg vial

Trade Names:
Etoposide
- Capsules 50 mg

Trade Names:
Toposar
- Injection, solution, concentrate 20 mg/mL

Indications and Usage

In combination with other chemotherapeutic agents in patients with small cell lung cancer.

Etopophos , Toposar

In combination with other chemotherapeutic agents in patients with refractory testicular tumors.

Unlabeled Uses

Bladder carcinoma, lymphomas, leukemias, Ewing sarcoma, Kaposi sarcoma, brain tumors, gestational trophoblastic tumors, ovarian germ cell tumors, rhabdomyosarcomas, Wilms tumor, bone marrow transplantation.

Contraindications

Standard considerations.

Dosage and Administration

Small Cell Lung Cancer
Adults

IV Dosage ranges from 35 mg/m ² /day for 4 days to 50 mg/m ² /day for 5 days. Repeat chemotherapy courses at 3- to 4-week intervals after adequate recovery from any toxicity. PO Two times the IV dose rounded to the nearest 50 mg.

Testicular Cancer
Adults

IV Dosage ranges from 50 to 100 mg/m ² /day on days 1 through 5 to 100 mg/m ² /day on days 1, 3, and 5. Repeat chemotherapy courses at 3- to 4-week intervals after adequate recovery from any toxicity.

Adjustment in Renal Insufficiency
Adults

For patients with CrCl of 15 to 50 mL/min, give 75% of the usual dose. Consider further dose reduction for those with CrCl less than 15 mL/min.