Adriamycin 50mg (doxyrubycin)

Adriamycin (doxorubicin) is a cancer (antineoplastic) medication. Doxorubicin interferes with the growth of cancer cells and slows their growth and spread in the body. Doxorubicin is used to treat many types of cancer. Doxorubicin may also be used for purposes other than those listed

Class: Anthracycline

Trade Names:
Adriamycin PFS
- Injection, preservative-free solution 2 mg/mL

Trade Names:
Adriamycin RDF
- Injection, lyophilized powder for solution 10 mg
- Injection, lyophilized powder for solution 20 mg
- Injection, lyophilized powder for solution 50 mg
- Injection, lyophilized powder for solution 150 mg

Trade Names:
Doxorubicin Hydrochloride
- Injection, lyophilized powder for solution 10 mg
- Injection, lyophilized powder for solution 20 mg
- Injection, lyophilized powder for solution 50 mg
- Solution for injection 2 mg/mL

Caelyx (Canada)
Myocet (Canada)

Indications and Usage

Produce regression of disseminated neoplastic conditions, such as acute lymphoblastic leukemia, acute myeloblastic leukemia, breast carcinoma, gastric carcinoma, Hodgkin disease, malignant lymphoma and bronchogenic carcinoma, neuroblastoma, ovarian carcinoma, soft tissue and bone sarcomas, thyroid carcinoma, transitional cell bladder carcinoma, Wilms tumor; component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

Unlabeled Uses

Refractory multiple myeloma; endometrial, islet cell, and lung carcinomas; AIDS-related Kaposi sarcoma.

Dosage and Administration

Single Agent Therapy
Adults and Children

IV 60 to 75 mg/m ² as a single dose every 21 days. Give the lower dose to patients with inadequate marrow reserves because of old age, prior therapy, or neoplastic marrow infiltration.

Combination Therapy
Adults

IV 40 to 60 mg/m ² as a single dose every 21 to 28 days.

Patients With Elevated Bilirubin
Dosage reduction

If serum bilirubin is 1.2 to 3 mg/dL, give 50% of adjusted dose from prior course. If serum bilirubin is 3.1 to 5 mg/dL, give 25% of adjusted dose from prior course.